Molecular Epidemiology of Streptococcus pneumoniae Detected in Hospitalized Pediatric Acute Respiratory Infection Cases in Central Vietnam

Streptococcus pneumoniae is the major bacterial pathogen causing high pneumonia morbidity and mortality in children <5 years of age. This study aimed to determine molecular epidemiology S. detected among hospitalized pediatric ARI cases at Khanh Hoa General Hospital, Nha Trang, Vietnam, from October 2015 September 2016 (pre-PCV). We performed semi-quantitative culture isolate pneumoniae. Serotyping, antimicrobial susceptibility testing, resistance gene detection multi-locus sequence typing were also performed. During period, 1300 enrolled 413 (31.8%) isolated. School attendance, age <3 old prior antibiotic use before admission positively associated with isolation. Major serotypes 6A/B (35.9%), 19F (23.7%) 23F (12.7%), which accounted for 80.3% vaccine-type pneumococci. High Clarithromycin, Erythromycin Clindamycin (86.7%, 85%, 78.2%) mutant drug-resistant genes pbp1A (98.1%), pbp2b (98.8%), pbp2x (99.6%) ermB (96.6%) mefA (30.3%) detected. MLST data showed genetic diversity isolates dominant ST 320 (21.2%) 13223 (19.3%), mainly found Vietnam. Non-typeables most new STs study. Vaccine-type pneumococcus macrolide commonly cases.